Membrane-bound and soluble Fas ligands have opposite functions in photoreceptor cell death following separation from the retinal pigment epithelium

Fas ligand (FasL) triggers apoptosis of Fas-positive cells, and previous reports described FasL-induced cell death of Fas-positive photoreceptors following a retinal detachment. However, as FasL exists in membrane-bound (mFasL) and soluble (sFasL) forms, and is expressed on resident microglia and in...

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Publicat a:Cell Death Dis
Autors principals: Matsumoto, H, Murakami, Y, Kataoka, K, Notomi, S, Mantopoulos, D, Trichonas, G, Miller, J W, Gregory, M S, Ksander, B R, Marshak-Rothstein, A, Vavvas, D G
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2015
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4670938/
https://ncbi.nlm.nih.gov/pubmed/26583327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2015.334
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