Overexpression of soluble Fas ligand following AAV gene therapy prevents retinal ganglion cell death in chronic and acute murine models of glaucoma

Glaucoma is a multifactorial disease resulting in the death of retinal ganglion cells (RGCs) and irreversible blindness. Glaucoma-associated RGC cell death depends on the pro-apoptotic and proinflammatory activity of membrane-bound FasL (mFasL). In contrast to mFasL, the natural soluble FasL cleavag...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: Krishnan, Anitha, Fei, Fei, Jones, Alexander, Busto, Patricia, Marshak-Rothstein, Ann, Ksander, Bruce R., Gregory-Ksander, Meredith
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5136323/
https://ncbi.nlm.nih.gov/pubmed/27849168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1601488
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