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Unfolded protein response-induced dysregulation of calcium homeostasis promotes retinal degeneration in rat models of autosomal dominant retinitis pigmentosa

The molecular mechanism of autosomal dominant retinitis pigmentosa (ADRP) in rats is closely associated with a persistently activated unfolded protein response (UPR). If unchecked, the UPR might trigger apoptosis, leading to photoreceptor death. One of the UPR-activated cellular signaling culminatin...

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Bibliografiske detaljer
Udgivet i:Cell Death Dis
Main Authors: Shinde, V, Kotla, P, Strang, C, Gorbatyuk, M
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4670931/
https://ncbi.nlm.nih.gov/pubmed/26844699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2015.325
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