An activated unfolded protein response promotes retinal degeneration and triggers an inflammatory response in the mouse retina

Recent studies on the endoplasmic reticulum stress have shown that the unfolded protein response (UPR) is involved in the pathogenesis of inherited retinal degeneration caused by mutant rhodopsin. However, the main question of whether UPR activation actually triggers retinal degeneration remains to...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Rana, T, Shinde, V M, Starr, C R, Kruglov, A A, Boitet, E R, Kotla, P, Zolotukhin, S, Gross, A K, Gorbatyuk, M S
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4454166/
https://ncbi.nlm.nih.gov/pubmed/25522272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.539
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