An activated unfolded protein response promotes retinal degeneration and triggers an inflammatory response in the mouse retina

Recent studies on the endoplasmic reticulum stress have shown that the unfolded protein response (UPR) is involved in the pathogenesis of inherited retinal degeneration caused by mutant rhodopsin. However, the main question of whether UPR activation actually triggers retinal degeneration remains to...

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Dettagli Bibliografici
Pubblicato in:Cell Death Dis
Autori principali: Rana, T, Shinde, V M, Starr, C R, Kruglov, A A, Boitet, E R, Kotla, P, Zolotukhin, S, Gross, A K, Gorbatyuk, M S
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2014
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4454166/
https://ncbi.nlm.nih.gov/pubmed/25522272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.539
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