Limited ATF4 Expression in Degenerating Retinas with Ongoing ER Stress Promotes Photoreceptor Survival in a Mouse Model of Autosomal Dominant Retinitis Pigmentosa

T17M rhodopsin expression in rod photoreceptors leads to severe retinal degeneration and is associated with the activation of ER stress related Unfolded Protein Response (UPR) signaling. Here, we show a novel role of a UPR transcription factor, ATF4, in photoreceptor cellular pathology. We demonstra...

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Publicado no:PLoS One
Principais autores: Bhootada, Yogesh, Kotla, Pravallika, Zolotukhin, Sergei, Gorbatyuk, Oleg, Bebok, Zsuzsanna, Athar, Mohammad, Gorbatyuk, Marina
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4856272/
https://ncbi.nlm.nih.gov/pubmed/27144303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0154779
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