Elevated α-synuclein caused by SNCA gene triplication impairs neuronal differentiation and maturation in Parkinson's patient-derived induced pluripotent stem cells

We have assessed the impact of α-synuclein overexpression on the differentiation potential and phenotypic signatures of two neural-committed induced pluripotent stem cell lines derived from a Parkinson's disease patient with a triplication of the human SNCA genomic locus. In parallel, comparati...

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Dades bibliogràfiques
Publicat a:Cell Death Dis
Autors principals: Oliveira, L M A, Falomir-Lockhart, L J, Botelho, M G, Lin, K-H, Wales, P, Koch, J C, Gerhardt, E, Taschenberger, H, Outeiro, T F, Lingor, P, Schüle, B, Arndt-Jovin, D J, Jovin, T M
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2015
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4670926/
https://ncbi.nlm.nih.gov/pubmed/26610207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2015.318
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