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Structural basis for cyclopropanation by a unique enoyl-acyl carrier protein reductase
The natural product curacin A, a potent anticancer agent, contains a rare cyclopropane group. The five enzymes for cyclopropane biosynthesis are highly similar to enzymes that generate a vinyl chloride moiety in the jamaicamide natural product. The structural biology of this remarkable catalytic ada...
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| Vydáno v: | Structure |
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| Hlavní autoři: | , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2015
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4670573/ https://ncbi.nlm.nih.gov/pubmed/26526850 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2015.09.013 |
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