Biochemical and Structural Basis of Triclosan Resistance in a Novel Enoyl-Acyl Carrier Protein Reductase

Enoyl-acyl carrier protein reductases (ENR), such as FabI, FabL, FabK, and FabV, catalyze the last reduction step in bacterial type II fatty acid biosynthesis. Previously, we reported metagenome-derived ENR homologs resistant to triclosan (TCL) and highly similar to 7-α hydroxysteroid dehydrogenase...

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Bibliografiske detaljer
Udgivet i:Antimicrob Agents Chemother
Main Authors: Khan, Raees, Zeb, Amir, Roy, Nazish, Thapa Magar, Roniya, Kim, Hyo Jeong, Lee, Keun Woo, Lee, Seon-Woo
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2018
Fag:
Mechanisms of Resistance
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6105837/
https://ncbi.nlm.nih.gov/pubmed/29891603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00648-18
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