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Dissecting seipin function: the localized accumulation of phosphatidic acid at ER/LD junctions in the absence of seipin is suppressed by Sei1p(ΔNterm) only in combination with Ldb16p

BACKGROUND: Seipin is required for the correct assembly of cytoplasmic lipid droplets. In the absence of the yeast seipin homolog Sei1p (formerly Fld1p), droplets are slow to bud from the endoplasmic reticulum, lack the normal component of proteins on their surface, are highly heterogeneous in size...

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Detalhes bibliográficos
Publicado no:BMC Cell Biol
Main Authors: Han, Sungwon, Binns, Derk D., Chang, Yu-Fang, Goodman, Joel M.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4670494/
https://ncbi.nlm.nih.gov/pubmed/26637296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12860-015-0075-3
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