Prediction of Adeno-Associated Virus Neutralizing Antibody Activity for Clinical Application

Patients with neutralizing antibodies (Nab) against adeno-associated virus (AAV) are usually excluded from treatment with AAV vectors. To develop a standard assay for detecting Nab inhibition activity, we systematically studied current AAV Nab assays in vitro and in vivo. Several factors were found...

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Vydáno v:Gene Ther
Hlavní autoři: Wang, Mei, Crosby, Ashley, Hastie, Eric, Samulski, Jade J., McPhee, Scott, Joshua, Grieger, Samulski, R. Jude, Li, Chengwen
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4670282/
https://ncbi.nlm.nih.gov/pubmed/26125606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gt.2015.69
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