Cathepsin D protects colorectal cancer cells from acetate-induced apoptosis through autophagy-independent degradation of damaged mitochondria

Acetate is a short-chain fatty acid secreted by Propionibacteria from the human intestine, known to induce mitochondrial apoptotic death in colorectal cancer (CRC) cells. We previously established that acetate also induces lysosome membrane permeabilization in CRC cells, associated with release of t...

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Bibliographische Detailangaben
Veröffentlicht in:Cell Death Dis
Hauptverfasser: Oliveira, C S F, Pereira, H, Alves, S, Castro, L, Baltazar, F, Chaves, S R, Preto, A, Côrte-Real, M
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2015
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4669836/
https://ncbi.nlm.nih.gov/pubmed/26086961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2015.157
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