Cathepsin D protects colorectal cancer cells from acetate-induced apoptosis through autophagy-independent degradation of damaged mitochondria

Acetate is a short-chain fatty acid secreted by Propionibacteria from the human intestine, known to induce mitochondrial apoptotic death in colorectal cancer (CRC) cells. We previously established that acetate also induces lysosome membrane permeabilization in CRC cells, associated with release of t...

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Detalles Bibliográficos
Publicado en:Cell Death Dis
Autores principales: Oliveira, C S F, Pereira, H, Alves, S, Castro, L, Baltazar, F, Chaves, S R, Preto, A, Côrte-Real, M
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2015
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4669836/
https://ncbi.nlm.nih.gov/pubmed/26086961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2015.157
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