Cathepsin D protects colorectal cancer cells from acetate-induced apoptosis through autophagy-independent degradation of damaged mitochondria

Acetate is a short-chain fatty acid secreted by Propionibacteria from the human intestine, known to induce mitochondrial apoptotic death in colorectal cancer (CRC) cells. We previously established that acetate also induces lysosome membrane permeabilization in CRC cells, associated with release of t...

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Publicat a:Cell Death Dis
Autors principals: Oliveira, C S F, Pereira, H, Alves, S, Castro, L, Baltazar, F, Chaves, S R, Preto, A, Côrte-Real, M
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2015
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4669836/
https://ncbi.nlm.nih.gov/pubmed/26086961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2015.157
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