p53 is active in murine stem cells and alters the transcriptome in a manner that is reminiscent of mutant p53

Since it was found that p53 is highly expressed in murine embryonic stem cells, it remained a mystery whether p53 is active in this cell type. We show that a significant part of p53 is localised in the nucleus of murine embryonic stem cells and that the majority of this nuclear p53 is bound to DNA....

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Dettagli Bibliografici
Pubblicato in:Cell Death Dis
Autori principali: Yan, H, Solozobova, V, Zhang, P, Armant, O, Kuehl, B, Brenner-Weiss, G, Blattner, C
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2015
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4669809/
https://ncbi.nlm.nih.gov/pubmed/25719246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2015.33
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