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p53 is active in murine stem cells and alters the transcriptome in a manner that is reminiscent of mutant p53
Since it was found that p53 is highly expressed in murine embryonic stem cells, it remained a mystery whether p53 is active in this cell type. We show that a significant part of p53 is localised in the nucleus of murine embryonic stem cells and that the majority of this nuclear p53 is bound to DNA....
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| Publicado no: | Cell Death Dis |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4669809/ https://ncbi.nlm.nih.gov/pubmed/25719246 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2015.33 |
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