Nuclear accumulation and activation of p53 in embryonic stem cells after DNA damage

BACKGROUND: P53 is a key tumor suppressor protein. In response to DNA damage, p53 accumulates to high levels in differentiated cells and activates target genes that initiate cell cycle arrest and apoptosis. Since stem cells provide the proliferative cell pool within organisms, an efficient DNA damag...

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Bibliografiske detaljer
Main Authors: Solozobova, Valeriya, Rolletschek, Alexandra, Blattner, Christine
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2009
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2704172/
https://ncbi.nlm.nih.gov/pubmed/19534768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2121-10-46
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