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Nuclear accumulation and activation of p53 in embryonic stem cells after DNA damage
BACKGROUND: P53 is a key tumor suppressor protein. In response to DNA damage, p53 accumulates to high levels in differentiated cells and activates target genes that initiate cell cycle arrest and apoptosis. Since stem cells provide the proliferative cell pool within organisms, an efficient DNA damag...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2704172/ https://ncbi.nlm.nih.gov/pubmed/19534768 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2121-10-46 |
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