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p53 stabilization in response to DNA damage requires Akt/PKB and DNA-PK
The p53 protein is one of the major tumor suppressor proteins. In response to DNA damage, p53 is prevented from degradation and accumulates to high levels. Ionizing radiation leads to hypophosphorylation of the p53 ubiquitin ligase Mdm2 at sites where phosphorylation is critical for p53 degradation...
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| Autors principals: | , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2008
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2409394/ https://ncbi.nlm.nih.gov/pubmed/18505846 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0703423105 |
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