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Glycogen Synthase Kinase 3-Dependent Phosphorylation of Mdm2 Regulates p53 Abundance

The Mdm2 oncoprotein regulates abundance and activity of the p53 tumor suppressor protein. For efficient degradation of p53, Mdm2 needs to be phosphorylated at several contiguous residues within the central conserved domain. We show that glycogen synthase kinase 3 (GSK-3) phosphorylated the Mdm2 pro...

詳細記述

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書誌詳細
主要な著者: Kulikov, Roman, Boehme, Karen A., Blattner, Christine
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology 2005
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC1190268/
https://ncbi.nlm.nih.gov/pubmed/16055726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.16.7170-7180.2005
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