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Glycogen Synthase Kinase 3-Dependent Phosphorylation of Mdm2 Regulates p53 Abundance

The Mdm2 oncoprotein regulates abundance and activity of the p53 tumor suppressor protein. For efficient degradation of p53, Mdm2 needs to be phosphorylated at several contiguous residues within the central conserved domain. We show that glycogen synthase kinase 3 (GSK-3) phosphorylated the Mdm2 pro...

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Detaylı Bibliyografya
Asıl Yazarlar: Kulikov, Roman, Boehme, Karen A., Blattner, Christine
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2005
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1190268/
https://ncbi.nlm.nih.gov/pubmed/16055726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.16.7170-7180.2005
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