CD59 signaling and membrane pores drive Syk-dependent erythrocyte necroptosis

Mature erythrocytes (red blood cells (RBCs)) undergo the programmed cell death (PCD) pathway of necroptosis in response to bacterial pore-forming toxins (PFTs) that target human CD59 (hCD59) but not hCD59-independent PFTs. Here, we investigate the biochemical mechanism of RBC necroptosis with a focu...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: LaRocca, T J, Stivison, E A, Mal-Sarkar, T, Hooven, T A, Hod, E A, Spitalnik, S L, Ratner, A J
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4669712/
https://ncbi.nlm.nih.gov/pubmed/26018734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2015.135
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