Human-Specific Bacterial Pore-Forming Toxins Induce Programmed Necrosis in Erythrocytes

A subgroup of the cholesterol-dependent cytolysin (CDC) family of pore-forming toxins (PFTs) has an unusually narrow host range due to a requirement for binding to human CD59 (hCD59), a glycosylphosphatidylinositol (GPI)-linked complement regulatory molecule. hCD59-specific CDCs are produced by seve...

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Autors principals: LaRocca, Timothy J., Stivison, Elizabeth A., Hod, Eldad A., Spitalnik, Steven L., Cowan, Peter J., Randis, Tara M., Ratner, Adam J.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Microbiology 2014
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4173772/
https://ncbi.nlm.nih.gov/pubmed/25161188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.01251-14
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