Optimizing cancer genome sequencing and analysis

Tumors are typically sequenced to depths of 75–100× (exome) or 30–50× (whole genome). We demonstrate that current sequencing paradigms are inadequate for tumors that are impure, aneuploid or clonally heterogeneous. To reassess optimal sequencing strategies, we performed ultra-deep (up to ~312×) whol...

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Detalhes bibliográficos
Publicado no:Cell Syst
Main Authors: Griffith, Malachi, Miller, Christopher A., Griffith, Obi L., Krysiak, Kilannin, Skidmore, Zachary L., Ramu, Avinash, Walker, Jason R., Dang, Ha X., Trani, Lee, Larson, David E., Demeter, Ryan T., Wendl, Michael C., McMichael, Joshua F., Austin, Rachel E., Magrini, Vincent, McGrath, Sean D., Ly, Amy, Kulkarni, Shashikant, Cordes, Matthew G., Fronick, Catrina C., Fulton, Robert S., Maher, Christopher A., Ding, Li, Klco, Jeffery M., Mardis, Elaine R., Ley, Timothy J., Wilson, Richard K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4669575/
https://ncbi.nlm.nih.gov/pubmed/26645048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cels.2015.08.015
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