Retinoid X receptor activation reverses age-related deficiencies in myelin debris phagocytosis and remyelination

The efficiency of central nervous system remyelination declines with age. This is in part due to an age-associated decline in the phagocytic removal of myelin debris, which contains inhibitors of oligodendrocyte progenitor cell differentiation. In this study, we show that expression of genes involve...

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Enregistré dans:
Détails bibliographiques
Publié dans:Brain
Auteurs principaux: Natrajan, Muktha S., de la Fuente, Alerie G., Crawford, Abbe H., Linehan, Eimear, Nuñez, Vanessa, Johnson, Kory R., Wu, Tianxia, Fitzgerald, Denise C., Ricote, Mercedes, Bielekova, Bibiana, Franklin, Robin J. M.
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2015
Sujets:
Original Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4668920/
https://ncbi.nlm.nih.gov/pubmed/26463675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/awv289
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