A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry

BACKGROUND: Pulmonary function decline is a major contributor to morbidity and mortality among smokers. Post bronchodilator FEV(1) and FEV(1)/FVC ratio are considered the standard assessment of airflow obstruction. We performed a genome-wide association study (GWAS) in 9919 current and former smoker...

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Udgivet i:BMC Genet
Main Authors: Lutz, Sharon M., Cho, Michael H., Young, Kendra, Hersh, Craig P., Castaldi, Peter J., McDonald, Merry-Lynn, Regan, Elizabeth, Mattheisen, Manuel, DeMeo, Dawn L., Parker, Margaret, Foreman, Marilyn, Make, Barry J., Jensen, Robert L., Casaburi, Richard, Lomas, David A., Bhatt, Surya P., Bakke, Per, Gulsvik, Amund, Crapo, James D., Beaty, Terri H., Laird, Nan M., Lange, Christoph, Hokanson, John E., Silverman, Edwin K.
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4668640/
https://ncbi.nlm.nih.gov/pubmed/26634245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12863-015-0299-4
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