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Metformin and Resveratrol Inhibited High Glucose-Induced Metabolic Memory of Endothelial Senescence through SIRT1/p300/p53/p21 Pathway

Endothelial senescence plays crucial roles in diabetic vascular complication. Recent evidence indicated that transient hyperglycaemia could potentiate persistent diabetic vascular complications, a phenomenon known as “metabolic memory.” Although SIRT1 has been demonstrated to mediate high glucose-in...

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Bibliographische Detailangaben
Veröffentlicht in:PLoS One
Hauptverfasser: Zhang, Erli, Guo, Qianyun, Gao, Haiyang, Xu, Ruixia, Teng, Siyong, Wu, Yongjian
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2015
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4668014/
https://ncbi.nlm.nih.gov/pubmed/26629991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0143814
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