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SIRT1 and p53, effect on cancer, senescence and beyond
NAD(+)-dependent Class III histone deacetylase SIRT1 is a multiple function protein critically involved in stress responses, cellular metabolism and aging through deacetylating a variety of substrates including p53, forkhead-box transcription factors, PGC-1α, NF-κB, Ku70 and histones. The first disc...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2010
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2989880/ https://ncbi.nlm.nih.gov/pubmed/20471503 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbapap.2010.05.002 |
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