SIRT1 alleviates senescence of degenerative human intervertebral disc cartilage endo-plate cells via the p53/p21 pathway

Cartilage end plates (CEP) degeneration plays an integral role in intervertebral disc (IVD) degeneration resulting from nutrient diffusion disorders. Although cell senescence resulting from oxidative stress is known to contribute to degeneration, no studies concerning the role of senescence in CEP d...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Zhou, Nian, Lin, Xin, Dong, Wen, Huang, Wei, Jiang, Wei, Lin, Liangbo, Qiu, Quanhe, Zhang, Xiaojun, Shen, Jieliang, Song, Zhaojun, Liang, Xi, Hao, Jie, Wang, Dawu, Hu, Zhenming
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4778056/
https://ncbi.nlm.nih.gov/pubmed/26940203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep22628
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