SIRT1 alleviates senescence of degenerative human intervertebral disc cartilage endo-plate cells via the p53/p21 pathway

Cartilage end plates (CEP) degeneration plays an integral role in intervertebral disc (IVD) degeneration resulting from nutrient diffusion disorders. Although cell senescence resulting from oxidative stress is known to contribute to degeneration, no studies concerning the role of senescence in CEP d...

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Enregistré dans:
Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Zhou, Nian, Lin, Xin, Dong, Wen, Huang, Wei, Jiang, Wei, Lin, Liangbo, Qiu, Quanhe, Zhang, Xiaojun, Shen, Jieliang, Song, Zhaojun, Liang, Xi, Hao, Jie, Wang, Dawu, Hu, Zhenming
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2016
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4778056/
https://ncbi.nlm.nih.gov/pubmed/26940203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep22628
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