SIRT1 protects against apoptosis by promoting autophagy in degenerative human disc nucleus pulposus cells

SIRT1 could protect degenerative human NP cells against apoptosis, and there were extensive and intimate connection between apoptosis and autophagy. Up to now, the role of autophagy in the process of human IVD degeneration is unclear. We sought to explore the relationship between autophagy and human...

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Udgivet i:Sci Rep
Main Authors: Jiang, Wei, Zhang, Xuemei, Hao, Jie, Shen, Jieliang, Fang, Ji, Dong, Wen, Wang, Dawu, Zhang, Xiaojun, Shui, Wei, Luo, Yi, Lin, Liangbo, Qiu, Quanhe, Liu, Bin, Hu, Zhenming
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4264007/
https://ncbi.nlm.nih.gov/pubmed/25503852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep07456
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