SIRT1 protects against apoptosis by promoting autophagy in degenerative human disc nucleus pulposus cells

SIRT1 could protect degenerative human NP cells against apoptosis, and there were extensive and intimate connection between apoptosis and autophagy. Up to now, the role of autophagy in the process of human IVD degeneration is unclear. We sought to explore the relationship between autophagy and human...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: Jiang, Wei, Zhang, Xuemei, Hao, Jie, Shen, Jieliang, Fang, Ji, Dong, Wen, Wang, Dawu, Zhang, Xiaojun, Shui, Wei, Luo, Yi, Lin, Liangbo, Qiu, Quanhe, Liu, Bin, Hu, Zhenming
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2014
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4264007/
https://ncbi.nlm.nih.gov/pubmed/25503852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep07456
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