SIRT1 alleviates senescence of degenerative human intervertebral disc cartilage endo-plate cells via the p53/p21 pathway

Cartilage end plates (CEP) degeneration plays an integral role in intervertebral disc (IVD) degeneration resulting from nutrient diffusion disorders. Although cell senescence resulting from oxidative stress is known to contribute to degeneration, no studies concerning the role of senescence in CEP d...

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Detaylı Bibliyografya
Yayımlandı:Sci Rep
Asıl Yazarlar: Zhou, Nian, Lin, Xin, Dong, Wen, Huang, Wei, Jiang, Wei, Lin, Liangbo, Qiu, Quanhe, Zhang, Xiaojun, Shen, Jieliang, Song, Zhaojun, Liang, Xi, Hao, Jie, Wang, Dawu, Hu, Zhenming
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2016
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4778056/
https://ncbi.nlm.nih.gov/pubmed/26940203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep22628
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