The G2385R Variant of Leucine-Rich Repeat Kinase 2 Associated with Parkinson's Disease is a Partial Loss of Function Mutation

Lignende værker

• Heterogeneity of Leucine-Rich Repeat Kinase 2 Mutations: Genetics, Mechanisms and Therapeutic Implications
  af: Rudenko, Iakov N., et al.
  Udgivet: (2014)
• Generation of fourteen isogenic cell lines for Parkinson’s disease-associated leucine-rich repeat kinase (LRRK2)
  af: Beylina, Aleksandra, et al.
  Udgivet: (2021)
• The G2385R risk factor for Parkinson’s disease enhances CHIP-dependent intracellular degradation of LRRK2
  af: Rudenko, Iakov N., et al.
  Udgivet: (2017)
• Differences in stability, activity and mutation effects between human and mouse Leucine-Rich Repeat Kinase 2
  af: Langston, Rebekah G., et al.
  Udgivet: (2018)
• The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson’s disease
  af: Cookson, Mark R.
  Udgivet: (2010)