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New Insight into Long-Range Nonadditivity within Protein Double-Mutant Cycles

Additivity principles in chemistry, biochemistry, and biophysics have been used extensively for decades. Nevertheless, it is well known that additivity frequently breaks down in complex biomacromolecules. Nonadditivity within protein double mutant free energy cycles of spatially close residue pairs...

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Bibliografske podrobnosti
izdano v:Proteins
Main Authors: Istomin, Andrei Y., Gromiha, M. Michael, Vorov, Oleg K., Jacobs, Donald J., Livesay, Dennis R.
Format: Artigo
Jezik:Inglês
Izdano: 2008
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4667956/
https://ncbi.nlm.nih.gov/pubmed/17803237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.21620
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