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Reaction Intermediate Analogues as Bisubstrate Inhibitors of Pantothenate Synthetase
The biosynthesis of pantothenate, the core of coenzyme A (CoA), has been considered an attractive target for the development of antimicrobial agents since this pathway is essential in prokaryotes, but absent in mammals. Pantothenate synthetase, encoded by the gene panC, catalyzes the final condensat...
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| Publicat a: | Bioorg Med Chem |
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| Autors principals: | , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2014
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4667779/ https://ncbi.nlm.nih.gov/pubmed/24507827 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2014.01.017 |
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