Reaction Intermediate Analogues as Bisubstrate Inhibitors of Pantothenate Synthetase

The biosynthesis of pantothenate, the core of coenzyme A (CoA), has been considered an attractive target for the development of antimicrobial agents since this pathway is essential in prokaryotes, but absent in mammals. Pantothenate synthetase, encoded by the gene panC, catalyzes the final condensat...

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Veröffentlicht in:Bioorg Med Chem
Hauptverfasser: Xu, Zhixiang, Yin, Wei, Martinelli, Leonardo K., Evans, Joanna, Chen, Jinglei, Yu, Yang, Wilson, Daniel J., Mizrahi, Valerie, Qiao, Chunhua, Aldrich, Courtney C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4667779/
https://ncbi.nlm.nih.gov/pubmed/24507827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2014.01.017
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