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Biochemical and Structural Characterization of Bisubstrate Inhibitors of BasE, the Self-standing Non-Ribosomal Peptide Synthetase Adenylate-Forming Enzyme of Acinetobactin Synthesis,(‡)

The human pathogen Acinetobacter baumannii produces a siderophore called acinetobactin that is derived from one molecule each of threonine, histidine, and 2,3-dihydroxybenzoic acid (DHB). The activity of several non-ribosomal peptide synthetase (NRPS) enzymes is used to combine the building blocks i...

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Bibliografiske detaljer
Main Authors: Drake, Eric J., Duckworth, Benjamin P., Neres, João, Aldrich, Courtney C., Gulick, Andrew M.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2964879/
https://ncbi.nlm.nih.gov/pubmed/20853905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi101226n
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