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LON is the master protease that protects against protein aggregation in human mitochondria through direct degradation of misfolded proteins

Maintenance of mitochondrial protein homeostasis is critical for proper cellular function. Under normal conditions resident molecular chaperones and proteases maintain protein homeostasis within the organelle. Under conditions of stress however, misfolded proteins accumulate leading to the activatio...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Bezawork-Geleta, Ayenachew, Brodie, Erica J., Dougan, David A., Truscott, Kaye N.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4667172/
https://ncbi.nlm.nih.gov/pubmed/26627475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep17397
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