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Two-Variance-Component Model Improves Genetic Prediction in Family Datasets

Genetic prediction based on either identity by state (IBS) sharing or pedigree information has been investigated extensively with best linear unbiased prediction (BLUP) methods. Such methods were pioneered in plant and animal-breeding literature and have since been applied to predict human traits, w...

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Bibliographische Detailangaben
Veröffentlicht in:Am J Hum Genet
Hauptverfasser: Tucker, George, Loh, Po-Ru, MacLeod, Iona M., Hayes, Ben J., Goddard, Michael E., Berger, Bonnie, Price, Alkes L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2015
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4667134/
https://ncbi.nlm.nih.gov/pubmed/26544803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2015.10.002
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