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Improving the Power of GWAS and Avoiding Confounding from Population Stratification with PC-Select
Using a reduced subset of SNPs in a linear mixed model can improve power for genome-wide association studies, yet this can result in insufficient correction for population stratification. We propose a hybrid approach using principal components that does not inflate statistics in the presence of popu...
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| Main Authors: | , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Genetics Society of America
2014
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4096359/ https://ncbi.nlm.nih.gov/pubmed/24788602 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.114.164285 |
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