Contrasting genetic architectures of schizophrenia and other complex diseases using fast variance components analysis

Heritability analyses of GWAS cohorts have yielded important insights into complex disease architecture, and increasing sample sizes hold the promise of further discoveries. Here, we analyze the genetic architecture of schizophrenia in 49,806 samples from the PGC, and nine complex diseases in 54,734...

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Detalhes bibliográficos
Publicado no:Nat Genet
Main Authors: Loh, Po-Ru, Bhatia, Gaurav, Gusev, Alexander, Finucane, Hilary K, Bulik-Sullivan, Brendan K, Pollack, Samuela J, de Candia, Teresa R, Lee, Sang Hong, Wray, Naomi R, Kendler, Kenneth S, O’Donovan, Michael C, Neale, Benjamin M, Patterson, Nick, Price, Alkes L
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4666835/
https://ncbi.nlm.nih.gov/pubmed/26523775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3431
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