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Mixed Model Association with Family-Biased Case-Control Ascertainment

Mixed models have become the tool of choice for genetic association studies; however, standard mixed model methods may be poorly calibrated or underpowered under family sampling bias and/or case-control ascertainment. Previously, we introduced a liability threshold-based mixed model association stat...

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Detalhes bibliográficos
Publicado no:Am J Hum Genet
Main Authors: Hayeck, Tristan J., Loh, Po-Ru, Pollack, Samuela, Gusev, Alexander, Patterson, Nick, Zaitlen, Noah A., Price, Alkes L.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5223022/
https://ncbi.nlm.nih.gov/pubmed/28017371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2016.11.015
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