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LD Score Regression Distinguishes Confounding from Polygenicity in Genome-Wide Association Studies
Both polygenicity (i.e., many small genetic effects) and confounding biases, such as cryptic relatedness and population stratification, can yield an inflated distribution of test statistics in genome-wide association studies (GWAS). However, current methods cannot distinguish between inflation from...
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| Publicado no: | Nat Genet |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4495769/ https://ncbi.nlm.nih.gov/pubmed/25642630 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3211 |
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