Germline Heterozygous Variants in SEC23B Are Associated with Cowden Syndrome and Enriched in Apparently Sporadic Thyroid Cancer

Cancer-predisposing genes associated with inherited cancer syndromes help explain mechanisms of sporadic carcinogenesis and often inform normal development. Cowden syndrome (CS) is an autosomal-dominant disorder characterized by high lifetime risks of epithelial cancers, such that ∼50% of affected i...

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Vydáno v:Am J Hum Genet
Hlavní autoři: Yehia, Lamis, Niazi, Farshad, Ni, Ying, Ngeow, Joanne, Sankunny, Madhav, Liu, Zhigang, Wei, Wei, Mester, Jessica L., Keri, Ruth A., Zhang, Bin, Eng, Charis
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4667132/
https://ncbi.nlm.nih.gov/pubmed/26522472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2015.10.001
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