Combining dehydration, construct optimization and improved data collection to solve the crystal structure of a CRM1–RanGTP–SPN1–Nup214 quaternary nuclear export complex

High conformational flexibility is an intrinsic and indispensable property of nuclear transport receptors, which makes crystallization and structure determination of macromolecular complexes containing exportins or importins particularly challenging. Here, the crystallization and structure determina...

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Vydáno v:Acta Crystallogr F Struct Biol Commun
Hlavní autoři: Monecke, Thomas, Dickmanns, Achim, Weiss, Manfred S., Port, Sarah A., Kehlenbach, Ralph H., Ficner, Ralf
Médium: Artigo
Jazyk:Inglês
Vydáno: International Union of Crystallography 2015
Témata:
Research Communications
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4666476/
https://ncbi.nlm.nih.gov/pubmed/26625290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2053230X15021524
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