A reconstituted system reveals how activating and inhibitory interactions control DDK dependent assembly of the eukaryotic replicative helicase

During G1-phase of the cell-cycle the replicative MCM2–7 helicase becomes loaded onto DNA into pre-replicative complexes (pre-RCs), resulting in MCM2–7 double-hexamers on DNA. In S-phase, Dbf4-dependent kinase (DDK) and cyclin-dependent-kinase (CDK) direct with the help of a large number of helicase...

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Detalles Bibliográficos
Publicado en:Nucleic Acids Res
Main Authors: Herrera, M. Carmen, Tognetti, Silvia, Riera, Alberto, Zech, Juergen, Clarke, Pippa, Fernández-Cid, Alejandra, Speck, Christian
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2015
Assuntos:
Genome Integrity, Repair and Replication
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4666391/
https://ncbi.nlm.nih.gov/pubmed/26338774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv881
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