The PYRIN domain-only protein POP1 inhibits inflammasome assembly and ameliorates inflammatory disease

In response to infections and tissue damage, ASC-containing inflammasome protein complexes are assembled that promote caspase-1 activation, IL-1β and IL-18 processing and release, pyroptosis, and the release of ASC particles. However, excessive or persistent activation of the inflammasome causes inf...

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Publicat a:Immunity
Autors principals: de Almeida, Lucia, Khare, Sonal, Misharin, Alexander V., Patel, Rajul, Ratsimandresy, Rojo A., Wallin, Melissa C., Perlman, Harris, Greaves, David R., Hoffman, Hal M., Dorfleutner, Andrea, Stehlik, Christian
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4666005/
https://ncbi.nlm.nih.gov/pubmed/26275995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2015.07.018
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