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A dRAStic RHOAdblock of Pyrin inflammasome activation
The Pyrin inflammasome guard is disabled if the activity of small cellular GTPase is compromised, in response to defects in the mevalonate pathway and directly by mutations in Pyrin, resulting in the IL-1β-driven autoinflammatory diseases MKD and FMF.
Enregistré dans:
| Publié dans: | Nat Immunol |
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| Auteurs principaux: | , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2016
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5110454/ https://ncbi.nlm.nih.gov/pubmed/27434003 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3511 |
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