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Mitochondrial division inhibitor 1 protects against mutant huntingtin-induced abnormal mitochondrial dynamics and neuronal damage in Huntington's disease

The objective of this study was to determine the protective effects of the mitochondrial division inhibitor 1 (Mdivi1) in striatal neurons that stably express mutant Htt (STHDhQ111/Q111) and wild-type (WT) Htt (STHDhQ7/Q7). Using gene expression analysis, biochemical methods, transmission electron m...

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Vydáno v:Hum Mol Genet
Hlavní autoři: Manczak, Maria, Reddy, P. Hemachandra
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4664169/
https://ncbi.nlm.nih.gov/pubmed/26464486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddv429
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