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Abnormal interaction between the mitochondrial fission protein Drp1 and hyperphosphorylated tau in Alzheimer's disease neurons: implications for mitochondrial dysfunction and neuronal damage

We recently reported increased mitochondrial fission and decreased fusion, increased amyloid beta (Aβ) interaction with the mitochondrial fission protein Drp1, increased mitochondrial fragmentation, impaired axonal transport of mitochondria and synaptic degeneration in neurons affected by AD. In the...

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Библиографические подробности
Главные авторы: Manczak, Maria, Reddy, P. Hemachandra
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2012
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3349426/
https://ncbi.nlm.nih.gov/pubmed/22367970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/dds072
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