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Abnormal interaction of VDAC1 with amyloid beta and phosphorylated tau causes mitochondrial dysfunction in Alzheimer's disease

The purpose of our study was to determine the relationship between voltage-dependent anion channel 1 protein (VDAC1) and amyloid beta (Aβ) and phosphorylated tau in Alzheimer's disease (AD). Using brain specimens from AD patients, control subjects and 6-, 12- and 24-month-old Aβ precursor prote...

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Autori principali: Manczak, Maria, Reddy, P. Hemachandra
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3490521/
https://ncbi.nlm.nih.gov/pubmed/22926141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/dds360
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