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Structure of Mycobacterium thermoresistibile GlgE defines novel conformational states that contribute to the catalytic mechanism
GlgE, an enzyme of the pathway that converts trehalose to α-glucans, is essential for Mycobacterium tuberculosis. Inhibition of GlgE, which transfers maltose from a maltose-1-phosphate donor to α-glucan/maltooligosaccharide chain acceptor, leads to a toxic accumulation of maltose-1-phosphate that cu...
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| Pubblicato in: | Sci Rep |
|---|---|
| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4663749/ https://ncbi.nlm.nih.gov/pubmed/26616850 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep17144 |
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